ATP:GTP 3'-pyrophosphotransferase ppGpp synthase I GTP pyrophosphokinase In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). Is required for actinomycin production. RELA_STRAT MPDEAQHLTAAKPDSAAGAAAEPAAHAQDGGGPVEHDRSAPADKPAERTRPKPAPPERPRPPPPRARAAGQPAARSGGSSNRVRARLARLGVQRANLTHPVLEPLLRIVRANDPKIETSTLRQIEKAYQVAERWHRGQKRKSGDPYITHPLAVTTILAELGMDPATLMAGLLHDSREDTEYGLDDLRRDFGDVVGLLVDGVTKLDKVKFGEAAQAETVRKMVVAMAKDPRVLVIKLADRLHNMRTMRYLKREKQEKKARETLEIYAPLAHRLGMNTIKWELEDLAFAILYPKMYDEIVRLVAERAPKRDEYLAIVTDEVQSDLRARRIKATVTGRPKHYYSVYQKIIVRGRDFAEIYDLVGIRVLVDTVRDCYAALGTVHARWNPVPGRFKDYIAMPKFNMYQSLHTTVIGPNGKPVELQIRTFDMHRRAEYGIAAHWKYKQEAVARASKVRTDVPKPAKGKDDHLNDMAWLRQLLDWQKETEDPGEFLESLRFDLSRNEVFVFTPKSDVIALPAGATPVDFAYAVHTEVGHRTIGARVNGRLVPLESTLDNGDLVEVFTSKAAGAGPSRDWLGFVKSPRARNKIRAWFSKERRDEAIEQGKDAIARAMRKQNLPIQRILTGDSLVTLAHEMRYPDISSSDAAIGEGHVGAQNVVQKLVQALGGEEAASEEIDEAVPSRSRSRKRRSNQDPGVVVKGVDDVWVKLARCCTPVPGEPIIGFVTRGSAVSVHRSDCVNVESLAREPERILEVEWAPTQSSVFLVAIQVEALDRSRLLSDVTRVLSDQHVNILSAAVQTSRDRVATSRFTFEMGDPKHLGHVLKAVRGVEGVYDVYRVTPGPQP 841 relA (p)ppGpp synthase